Modeling panic disorder in rodents
Moreira FA, Gobira PH, Viana TG, Vicente MA, Zangrossi H, Graeff FG Cell Tissue Res. 2013 Oct;354(1):119-25 PMID: 23584609 Abstract Panic disorder (PD) is a subtype of anxiety disorder in which the core phenomenon is the spontaneous occurrence of panic attacks. Although studies with laboratory animals have been instrumental for the understanding of its neurobiology […]
Evaluating emotional sensitivity and tolerance factors in the prediction of panic-relevant responding to a biological challenge
Kutz A, Marshall E, Bernstein A, Zvolensky MJ J Anxiety Disord 2010 Jan;24(1):16-22 PMID: 19720496 Abstract The current study investigated anxiety sensitivity, distress tolerance (Simons & Gaher, 2005), and discomfort intolerance (Schmidt, Richey, Cromer, & Buckner, 2007) in relation to panic-relevant responding (i.e., panic attack symptoms and panic-relevant cognitions) to a 10% carbon dioxide enriched […]
Relapse following combined treatment discontinuation in a placebo-controlled trial for panic disorder
Raffa SD, Stoddard JA, White KS, Barlow DH, Gorman JM, Shear MK, Woods SW J. Nerv. Ment. Dis. 2008 Jul;196(7):548-55 PMID: 18626295 Abstract A recent double-blind, placebo-controlled trial (Barlow et al., 2000 JAMA. 283:2529-2536) examined separate and synergistic effects of psychological and pharmacological treatments for panic disorder. One finding warranting further investigation involved relatively high […]
Personality disorder traits as predictors of subsequent first-onset panic disorder or agoraphobia
Bienvenu OJ, Stein MB, Samuels JF, Onyike CU, Eaton WW, Nestadt G Compr Psychiatry 2009 May-Jun;50(3):209-14 PMID: 19374963 Abstract Determining how personality disorder traits and panic disorder and/or agoraphobia relate longitudinally is an important step in developing a comprehensive understanding of the etiology of panic/agoraphobia. In 1981, a probabilistic sample of adult (> or =18 […]
Economic burden of not recognizing panic disorder in the emergency department
Coley KC, Saul MI, Seybert AL J Emerg Med 2009 Jan;36(1):3-7 PMID: 17933481 Abstract The objective of this cohort study was to examine the diagnostic patterns and resource utilization of patients presenting to the Emergency Department with chest pain of unknown origin who may be experiencing a panic attack. Patients were excluded if they had […]
Gender-specific abnormalities in the serotonin transporter system in panic disorder
Cannon DM, Klaver JM, Klug SA, Carlson PJ, Luckenbaugh DA, Ichise M, Drevets WC Int. J. Neuropsychopharmacol. 2013 May;16(4):733-43 PMID: 22953744 Abstract The central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover, reduced pre- and post-synaptic 5-HT(1A)-receptor sensitivity and binding and clinical improvement during administration […]
Respiratory irregularity and stress hormones in panic disorder: exploring potential linkages
Abelson JL, Khan S, Lyubkin M, Giardino N Depress Anxiety 2008;25(10):885-7 PMID: 17557312 Abstract Dysregulation within both respiratory control systems and the hypothalamic-pituitary adrenal (HPA) axis has been implicated in the pathophysiological of panic disorder. However, potential linkages between respiration and the HPA axis have rarely been examined in panic patients. We have previously published […]
Panic disorder and dissociation - comparison with healthy controls
Pastucha P, Prasko J, Grambal A, Latalova K, Sigmundova Z, Sykorova T, Tichackova A Neuro Endocrinol. Lett. 2009;30(6):774-8 PMID: 20038926 Abstract OBJECTIVE: According to recent findings, clinical symptoms of the patients suffering from panic disorder are related to dissociation. The aim of our study is to examine if the dissociation, can influence the intensity of […]
Cognitive behavior therapy in the treatment of panic disorder
Manjula M, Kumariah V, Prasadarao PS, Raguram R Indian J Psychiatry 2009 Apr;51(2):108-16 PMID: 19823629 Abstract BACKGROUND: Comprehensive cognitive behavior therapies have been proved to be more effective than behavioral interventions. However, the efficacy of CBT is not studied in the Indian context and also, the amount of change brought about by CBT is not […]
Duloxetine-related panic attacks
Sabljić V, Rakun R, Ružić K, Grahovac T Psychiatr Danub 2011 Mar;23(1):114-6 PMID: 21448113 Abstract Side-effects arising on the grounds of antidepressant administration pose as a substantial obstacle hindering successful depressive disorder treatment. Side-effects, especially those severe or those manifested through dramatic clinical presentations such as panic attacks, make the treatment far more difficult and […]
Current findings of fMRI in panic disorder: contributions for the fear neurocircuitry and CBT effects
de Carvalho MR, Dias GP, Cosci F, de-Melo-Neto VL, Bevilaqua MC, Gardino PF, Nardi AE Expert Rev Neurother 2010 Feb;10(2):291-303 PMID: 20136384 Abstract Thanks to brain imaging great advances have been made concerning the comprehension of neural substrates related to panic disorder (PD). This article aims to: review the recent functional MRI (fMRI) studies concerning […]
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy
Reif A, Richter J, Straube B, Höfler M, Lueken U, Gloster AT, Weber H, Domschke K, Fehm L, Ströhle A, Jansen A, Gerlach A, Pyka M, Reinhardt I, Konrad C, Wittmann A, Pfleiderer B, Alpers GW, Pauli P, Lang T, Arolt V, Wittchen HU, Hamm A, Kircher T, Deckert J Mol. Psychiatry 2014 Jan;19(1):122-8 PMID: […]
Respiratory pathophysiology of panic disorder: an ambulatory monitoring study
Pfaltz MC, Michael T, Grossman P, Blechert J, Wilhelm FH Psychosom Med 2009 Oct;71(8):869-76 PMID: 19737858 Abstract OBJECTIVE: To assess the external validity of laboratory baselines in panic disorder (PD), frequently associated with respiratory pattern abnormalities like increased respiratory variability and sighing, implying a stable pathophysiologic trait characteristic. METHODS: Physical activity and a variety of […]
Is internet-based CBT for panic disorder and agoraphobia as effective as face-to-face CBT?
Kiropoulos LA, Klein B, Austin DW, Gilson K, Pier C, Mitchell J, Ciechomski L J Anxiety Disord 2008 Dec;22(8):1273-84 PMID: 18289829 Abstract This study compared Panic Online (PO), an internet-based CBT intervention, to best-practice face-to-face CBT for people with panic disorder with or without agoraphobia. Eighty-six people with a primary diagnosis of panic disorder were […]
The course of panic attacks in individuals with panic disorder and subthreshold panic disorder: a population-based study
Batelaan NM, de Graaf R, Spijker J, Smit JH, van Balkom AJ, Vollebergh WA, Beekman AT J Affect Disord 2010 Feb;121(1-2):30-8 PMID: 19477529 Abstract BACKGROUND: Although panic disorder is generally considered to be a chronic condition, little is known about the natural history of panic attacks and the factors predicting the prognosis of panic. It […]
Temporal lobe epilepsy confused with panic disorder: implications for treatment
Deutsch SI, Rosse RB, Sud IM, Burket JA Clin Neuropharmacol 2009 May-Jun;32(3):160-2 PMID: 19483484 Abstract A 34-year-old woman with a 9-year history of unprovoked attacks of anxiety and dyspnea associated with symptoms of depersonalization and derealization is presented. The attacks increased in frequency and were associated with internal derogatory voices, vivid frightening imagery, and suicidal […]
An examination of the structure of posttraumatic stress disorder in relation to the anxiety and depressive disorders
Forbes D, Lockwood E, Elhai JD, Creamer M, O'Donnell M, Bryant R, McFarlane A, Silove D J Affect Disord 2011 Jul;132(1-2):165-72 PMID: 21496930 Abstract The nature and structure of posttraumatic stress disorder (PTSD) has been the subject of much interest in recent times. This research has been represented by two streams, the first representing a […]
Cost-effectiveness analysis of an occupational therapy-led lifestyle approach and routine general practitioner's care for panic disorder
Lambert RA, Lorgelly P, Harvey I, Poland F Soc Psychiatry Psychiatr Epidemiol 2010 Jul;45(7):741-50 PMID: 19688282 Abstract OBJECTIVE: To assess the cost-effectiveness of an occupational therapy-led lifestyle approach to treating panic disorder in primary care compared with routine general practitioner's (GP) care. The burden of mental health disorders is considerable. Cost-effective interventions are necessary to […]
Treatment of panic in chest pain patients from emergency departments: efficacy of different interventions focusing on panic management
Marchand A, Belleville G, Fleet R, Dupuis G, Bacon SL, Poitras J, Chauny JM, Vadeboncoeur A, Lavoie KL Gen Hosp Psychiatry 2012 Nov-Dec;34(6):671-80 PMID: 22840563 Abstract OBJECTIVE: The aim was to assess the efficacy of two brief cognitive-behavioral therapy (CBT)-based interventions (7×1-h sessions and 1×2-h session) and a pharmacological treatment (paroxetine), compared to supportive usual […]
Respiratory patterns in panic disorder reviewed: a focus on biological challenge tests
Niccolai V, van Duinen MA, Griez EJ Acta Psychiatr Scand 2009 Sep;120(3):167-77 PMID: 19548964 Abstract OBJECTIVE: To provide a systematic review of studies investigating respiration in PD and comments on relative inconsistencies. METHOD: A Medline search of controlled studies focusing on pCO(2), respiratory rate, tidal volume, and minute volume in PD patients was conducted for […]
Personality subtypes in patients with panic disorder
Powers A, Westen D Compr Psychiatry 2009 Mar-Apr;50(2):164-72 PMID: 19216894 Abstract OBJECTIVE: This study examined personality subtypes of adults diagnosed with panic disorder (PD). METHODS: As part of a National Institute of Mental Health-funded study on personality in a clinical population, randomly selected psychologists and psychiatrists used a Q-sort instrument to describe 96 adults diagnosed […]
A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder
Kim YK, Lee HJ, Yang JC, Hwang JA, Yoon HK Behav. Genet. 2009 Mar;39(2):170-5 PMID: 19132526 Abstract Panic disorder (PD) is a complex and heterogeneous psychiatric condition. Dysfunction within the serotonergic system has been hypothesized to play an important role in PD. The novel brain-specific serotonin synthesizing enzyme, tryptophan hydroxylase 2 (TPH2), which represents the […]
Effects of reversible inactivation of the dorsomedial hypothalamus on panic- and anxiety-related responses in rats
Nascimento JO, Zangrossi H, Viana MB Braz. J. Med. Biol. Res. 2010 Sep;43(9):869-73 PMID: 20694443 Abstract The medial hypothalamus is part of a neurobiological substrate controlling defensive behavior. It has been shown that a hypothalamic nucleus, the dorsomedial hypothalamus (DMH), is involved in the regulation of escape, a defensive behavior related to panic attacks. The […]
An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus
Johnson PL, Shekhar A Physiol. Behav. 2012 Dec;107(5):686-98 PMID: 22484112 Abstract Panic disorder (PD) is a severe anxiety disorder characterized by susceptibility to induction of panic attacks by subthreshold interoceptive stimuli such as sodium lactate infusions or hypercapnia induction. Here we review a model of panic vulnerability in rats involving chronic inhibition of GABAergic tone […]
Selective serotonin-reuptake inhibitors in the treatment of panic disorder: a systematic review of placebo-controlled studies
Mochcovitch MD, Nardi AE Expert Rev Neurother 2010 Aug;10(8):1285-93 PMID: 20662754 Abstract The selective serotonin-reuptake inhibitors are widely used in clinical practice in the treatment of panic disorder (PD). This article undertakes an up-to-date, systematic review of the published double-blind, placebo-controlled, randomized, short-term studies with currently available selective serotonin-reuptake inhibitors in the treatment of PD. […]
Carbon dioxide induction of panic anxiety in schizophrenia with auditory hallucinations
Savitz AJ, Kahn TA, McGovern KE, Kahn JP Psychiatry Res 2011 Aug;189(1):38-42 PMID: 21719111 Abstract Panic is commonly co-morbid with schizophrenia. Panic may emerge prodromally, contribute to specific psychotic symptoms, and predict medication response. Panic is often missed due to agitation, impaired cognition, psychotic symptom overlap and limited clinician awareness. Carbon dioxide exposure has been […]
Agoraphobic cognitions in old and young patients with panic disorder
Hendriks GJ, Keijsers GP, Kampman M, Voshaar RC, Hoogduin CA Am J Geriatr Psychiatry 2010 Dec;18(12):1155-8 PMID: 20808090 Abstract OBJECTIVES: To compare the agoraphobic cognitions of younger and older patients suffering from panic disorder with agoraphobia by means of existing questionnaires. METHOD: Agoraphobic cognitions were assessed using the Agoraphobic Cognitions Questionnaire (ACQ) in 205 patients […]
Cognitive behavior therapy for panic disorder
Freedman S, Adessky R Isr J Psychiatry Relat Sci 2009;46(4):251-6 PMID: 20635771 Abstract Panic Disorder affects around 3.5% of the population during their lifetime, affecting twice as many women. It is often comorbid with depression and other anxiety disorders. Panic disorder can be assessed by a variety of interviews and self-report questionnaires. The theoretical model […]
Anxiety, panic disorder and coronary artery disease: issues concerning physical exercise and cognitive behavioral therapy
Sardinha A, Araújo CG, Soares-Filho GL, Nardi AE Expert Rev Cardiovasc Ther 2011 Feb;9(2):165-75 PMID: 21453213 Abstract Psychological factors such as stress and depression have already been established as primary and secondary cardiovascular risk factors. More recently, the role of anxiety in increasing cardiac risk has also been studied. The underlying mechanisms of increased cardiac […]
Neurobiology of panic and pH chemosensation in the brain
Wemmie JA Dialogues Clin Neurosci 2011;13(4):475-83 PMID: 22275852 Abstract Panic disorder is a common and disabling illness for which treatments are too frequently ineffective. Greater knowledge of the underlying biology could aid the discovery of better therapies. Although panic attacks occur unpredictably, the ability to provoke them in the laboratory with challenge protocols provides an […]
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