Obsessive-compulsive disorder is associated with less of a distinction between specific acts of omission and commission
Siev J, Huppert JD, Chambless DL J Anxiety Disord 2010 Dec;24(8):893-9 PMID: 20637565 Abstract Individuals with obsessive-compulsive disorder (OCD) seem to judge harm caused actively and passively as morally equivalent. In contrast, people generally choose harm by omission over harm by commission, a propensity known as omission bias. Two studies examined the hypothesis that OCD […]
The AmpliChip® CYP450 test and response to treatment in schizophrenia and obsessive compulsive disorder: a pilot study and focus on cases with abnormal CYP2D6 drug metabolism
Müller DJ, Brandl EJ, Hwang R, Tiwari AK, Sturgess JE, Zai CC, Lieberman JA, Kennedy JL, Richter MA Genet Test Mol Biomarkers 2012 Aug;16(8):897-903 PMID: 22775532 Abstract AIM: Genetic factors can result in variance in drug metabolism enzyme function, which is one major mechanism impacting on interindividual variability in response and side effects. We therefore […]
The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: an experimental study in the monkey
Rotge JY, Aouizerate B, Amestoy V, Lambrecq V, Langbour N, Nguyen TH, Dovero S, Cardoit L, Tignol J, Bioulac B, Burbaud P, Guehl D Transl Psychiatry 2012;2:e161 PMID: 23010765 Abstract Obsessive-compulsive disorder (OCD) is a frequent psychiatric disorder characterized by repetitive intrusive thoughts and severe anxiety, leading to compulsive behaviors. Although medical treatment is effective […]
A randomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorder
Kang JI, Kim CH, Namkoong K, Lee CI, Kim SJ J Clin Psychiatry 2009 Dec;70(12):1645-51 PMID: 19709504 Abstract OBJECTIVE: The present study investigated possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex and supplementary motor area in patients with treatment-resistant obsessive-compulsive disorder. METHOD: Between […]
Treatment of obsessive-compulsive disorder complicated by comorbid eating disorders
Simpson HB, Wetterneck CT, Cahill SP, Steinglass JE, Franklin ME, Leonard RC, Weltzin TE, Riemann BC Cogn Behav Ther 2013;42(1):64-76 PMID: 23316878 Abstract Purpose: Eating disorders and obsessive-compulsive disorder (OCD) commonly co-occur, but there is little data for how to treat these complex cases. To address this gap, we examined the naturalistic outcome of 56 […]
Longitudinal course of obsessive-compulsive disorder in patients with anxiety disorders: a 15-year prospective follow-up study
Marcks BA, Weisberg RB, Dyck I, Keller MB Compr Psychiatry 2011 Nov-Dec;52(6):670-7 PMID: 21349511 Abstract BACKGROUND: Although obsessive-compulsive disorder (OCD) is typically described as a chronic condition, relatively little is known about the naturalistic, longitudinal course of the disorder. The purpose of the current study was to examine the probability of OCD remission and recurrence […]
Suicide in patients treated for obsessive-compulsive disorder: a prospective follow-up study
Alonso P, Segalàs C, Real E, Pertusa A, Labad J, Jiménez-Murcia S, Jaurrieta N, Bueno B, Vallejo J, Menchón JM J Affect Disord 2010 Aug;124(3):300-8 PMID: 20060171 Abstract BACKGROUND: To describe the occurrence of persistent suicidal ideation and suicide attempts in a sample of obsessive-compulsive patients followed-up prospectively during 1 to 6years, and to determine […]
Association of the candidate gene SLC1A1 and obsessive-compulsive disorder in Han Chinese population
Wu H, Wang X, Yu S, Wang D, Chen J, Jiang K, Zhu L, Xiao Z, Fralick D Psychiatry Res 2013 Oct;209(3):737-9 PMID: 23411042 Abstract This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic […]
Hypochondriasis and obsessive-compulsive disorder in schizophrenic patients treated with clozapine vs other atypical antipsychotics
Grassi G, Poli L, Cantisani A, Righi L, Ferrari G, Pallanti S CNS Spectr 2013 Nov;:1-7 PMID: 24176043 Abstract OBJECTIVE: The aim of the study was to investigate the prevalence rates of obsessive-compulsive disorder (OCD) and hypochondriasis in schizophrenic patients treated with atypical antipsychotics (AAPs) and to investigate the different comorbidity rates of OCD and […]
Chronic catatonia with obsessive compulsive disorder symptoms treated with lorazepam, memantine, aripiprazole, fluvoxamine and neurosurgery
Mukai Y, Two A, Jean-Baptiste M BMJ Case Rep 2011;2011 PMID: 22687661 Abstract Catatonia is a syndrome with protean manifestations and multiple aetiologies. In this report, the authors describe the case of a young woman who presented for care after a 13-year period of catatonia-like symptoms, including mutism, refusal to eat and persistent neck flexion. […]
Perceived parental rearing in subjects with obsessive-compulsive disorder and their siblings
Lennertz L, Grabe HJ, Ruhrmann S, Rampacher F, Vogeley A, Schulze-Rauschenbach S, Ettelt S, Meyer K, Kraft S, Reck C, Pukrop R, John U, Freyberger HJ, Klosterkötter J, Maier W, Falkai P, Wagner M Acta Psychiatr Scand 2010 Apr;121(4):280-8 PMID: 19694627 Abstract OBJECTIVE: Perceived parenting in patients suffering from obsessive-compulsive disorder (OCD) is examined. We […]
Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
Okada K, Ota T, Iida J, Kishimoto N, Kishimoto T Prog. Neuropsychopharmacol. Biol. Psychiatry 2013 Jun;43:7-13 PMID: 23220093 Abstract Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a […]
Development of a computer-based behavioral assessment of checking behavior in obsessive-compulsive disorder
Kim K, Kim SI, Cha KR, Park J, Rosenthal MZ, Kim JJ, Han K, Kim IY, Kim CH Compr Psychiatry 2010 Jan-Feb;51(1):86-93 PMID: 19932831 Abstract OBJECTIVE: The goal of the current study was to develop and obtain preliminary psychometric data for a computer-based behavioral measure of compulsive checking behavior in a sample of patients with […]
Clinical predictors of health-related quality of life in obsessive-compulsive disorder
Albert U, Maina G, Bogetto F, Chiarle A, Mataix-Cols D Compr Psychiatry 2010 Mar-Apr;51(2):193-200 PMID: 20152302 Abstract BACKGROUND: Obsessive-compulsive disorder (OCD) is a serious mental disorder that has severe impact on a person's quality of life and those living with a person with OCD. This study systematically examined the clinical variables that are predictive of […]
Obsessive-compulsive disorder in postmenopausal women: prevalence, clinical features, and comorbidity
Uguz F, Sahingoz M, Gezginc K, Karatayli R Aust N Z J Psychiatry 2010 Feb;44(2):183-7 PMID: 20113307 Abstract OBJECTIVE: Studies about obsessive-compulsive disorder (OCD) during the postmenopausal period have been insufficient. The purpose of the current study was therefore to examine the prevalence rate, clinical characteristics, and comorbidity of OCD in postmenopausal women. METHODS: A […]
Major depressive disorder in a family study of obsessive-compulsive disorder with pediatric probands
Hanna GL, Himle JA, Hanna BS, Gold KJ, Gillespie BW Depress Anxiety 2011 Jun;28(6):501-8 PMID: 21538726 Abstract OBJECTIVE: This study examined the comorbidity of obsessive-compulsive disorder (OCD) with major depressive disorder (MDD) in a family study of OCD with pediatric probands. METHOD: This study assessed the lifetime prevalence of MDD in 141 first-degree relatives (FDR) […]
Eating disorders in patients with obsessive-compulsive disorder: prevalence and clinical correlates
Sallet PC, de Alvarenga PG, Ferrão Y, de Mathis MA, Torres AR, Marques A, Hounie AG, Fossaluza V, do Rosario MC, Fontenelle LF, Petribu K, Fleitlich-Bilyk B Int J Eat Disord 2010 May;43(4):315-25 PMID: 19424977 Abstract OBJECTIVE: The objective is to evaluate the prevalence and associated clinical characteristics of eating disorders (ED) in patients with […]
Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?
Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S Psychiatry Res 2010 May;177(1-2):263-5 PMID: 20106536 Abstract Obsessive-compulsive disorder (OCD) is a common psychiatric illness. Although the aetiology of OCD is still unknown, the family-genetic data show that familial forms of OCD may be associated with a specific genetic susceptibility. Recent investigations have […]
Impact of obsessive-compulsive symptoms in Tourette's syndrome on neuropsychological performance
Matsuda N, Kono T, Nonaka M, Shishikura K, Konno C, Kuwabara H, Shimada T, Kano Y Psychiatry Clin. Neurosci. 2012 Apr;66(3):195-202 PMID: 22369455 Abstract AIM: Although inconsistencies in neuropsychological impairments in Tourette's syndrome (TS) have been discussed with respect to comorbid disorders, such as obsessive-compulsive disorder, few studies have focused on the specific dimensions of […]
Group versus individual cognitive treatment for obsessive-compulsive disorder: Changes in severity at post-treatment and one-year follow-up
Cabedo E, Belloch A, Carrió C, Larsson C, Fernández-Alvarez H, García F Behav Cogn Psychother 2010 Mar;38(2):227-32 PMID: 20025836 Abstract BACKGROUND: Very few studies have compared the efficacy of individual and group cognitive behaviour therapy (CBT) for the treatment of Obsessive-Compulsive Disorder (OCD) by taking into consideration the change in OCD severity in both the […]
Increased N-Acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients
Fan Q, Tan L, You C, Wang J, Ross CA, Wang X, Zhang T, Li J, Chen K, Xiao Z Psychiatry Clin. Neurosci. 2010 Oct;64(5):483-90 PMID: 20923427 Abstract AIMS: Changes in the fronto-striato-thalamo-cortical-circuit loop have been suggested in the pathogenesis of obsessive-compulsive disorder (OCD), and have been studied using (1)H magnetic resonance spectroscopy ((1)H MRS) […]
Prestimulus top-down reflection of obsessive-compulsive disorder in EEG frontal theta and occipital alpha oscillations
Min BK, Kim SJ, Park JY, Park HJ Neurosci. Lett. 2011 Jun;496(3):181-5 PMID: 21527316 Abstract It has recently been reported that prestimulus electroencephalogram (EEG) frontal theta and occipital alpha oscillations of healthy controls were modulated by the type of upcoming tasks, reflecting prestimulus top-down preparation. The present study explored the differences in dynamics of frontal […]
Lamotrigine augmentation of serotonin reuptake inhibitors in severe and long-term treatment-resistant obsessive-compulsive disorder
Arrojo-Romero M, Tajes Alonso M, de Leon J Case Rep Psychiatry 2013;2013:612459 PMID: 23936714 Abstract The treatment recommendations in obsessive-compulsive disorder (OCD) after lack of response to selective serotonin reuptake inhibitors (SSRIs) include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor (SRI), or antipsychotics. We present two cases of response to […]
Factors associated with poor response in cognitive-behavioral therapy for pediatric obsessive-compulsive disorder
Storch EA, Björgvinsson T, Riemann B, Lewin AB, Morales MJ, Murphy TK Bull Menninger Clin 2010;74(2):167-85 PMID: 20545494 Abstract Cognitive-behavioral therapy (CBT) with exposure and response prevention has proved to be an effective intervention for youth with obsessive-compulsive disorder (OCD). Given advantages over psychiatric medications (i.e., serotonin reuptake inhibitors) based on superior safety, maintenance of […]
Neurological soft signs in obsessive compulsive disorder with good and poor insight
Karadag F, Tumkaya S, Kırtaş D, Efe M, Alacam H, Oguzhanoglu NK Prog. Neuropsychopharmacol. Biol. Psychiatry 2011 Jun;35(4):1074-9 PMID: 21396423 Abstract OBJECTIVE: Obsessive compulsive disorder (OCD) is a clinically heterogeneous disorder; OCD with poor insight has been suggested to be a specific clinical subtype. Neurological soft signs (NSSs) may be helpful to identify the specific […]
Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder
Alonso P, Gratacòs M, Segalàs C, Escaramís G, Real E, Bayés M, Labad J, Pertusa A, Vallejo J, Estivill X, Menchón JM Psychoneuroendocrinology 2011 May;36(4):473-83 PMID: 20850223 Abstract Compelling data from animal and clinical studies suggest that sex steroids may play a role in the etiopathology of obsessive-compulsive disorder (OCD). The aim of this study […]
Trial-by-Trial Adjustments of Cognitive Control Following Errors and Response Conflict are Altered in Pediatric Obsessive Compulsive Disorder
Liu Y, Gehring WJ, Weissman DH, Taylor SF, Fitzgerald KD Front Psychiatry 2012;3:41 PMID: 22593744 Abstract Background: Impairments of cognitive control have been theorized to drive the repetitive thoughts and behaviors of obsessive compulsive disorder (OCD) from early in the course of illness. However, it remains unclear whether altered trial-by-trial adjustments of cognitive control characterize […]
The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication
Ruscio AM, Stein DJ, Chiu WT, Kessler RC Mol. Psychiatry 2010 Jan;15(1):53-63 PMID: 18725912 Abstract Despite significant advances in the study of obsessive-compulsive disorder (OCD), important questions remain about the disorder's public health significance, appropriate diagnostic classification, and clinical heterogeneity. These issues were explored using data from the National Comorbidity Survey Replication, a nationally representative […]
[Irrational anxiety: obsessive-compulsive disorder]
Vera L Rev Prat 2010 Jun;60(6):793-5 PMID: 20623895 Abstract Obsessive-compulsive disorder is an exemplar of an anxiety disorder where irrational thoughts and compulsive behaviors succeed each other in a mental system where every negative outcome can occur. Affects like doubt and guilt reinforce the need to prevent catastrophic consequences from occurring. Magical thinking replaces logical […]
Sudden gains in the treatment of obsessive-compulsive disorder
Aderka IM, Anholt GE, van Balkom AJ, Smit JH, Hermesh H, van Oppen P Psychother Psychosom 2012;81(1):44-51 PMID: 22116471 Abstract BACKGROUND: The present study examined sudden gains during treatment for obsessive-compulsive disorder (OCD) and their relationship to short- and long-term outcome. METHODS: Ninety-one individuals (age 19-64) completed either cognitive treatment, exposure treatment, or their combination […]
Recent Comments